Structure of PDB 7rq0 Chain A

Receptor sequence
>7rq0A (length=137) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAGQETAYFLLKLAGRW
PVKTVHTDNGSNFTSTTVKAACEWAGIKQEFGIPESMNKELKKIIGQVRD
QAEHLKTAVQMAVFIHNKKRGGYSAGERIVDIIATDI
3D structure
PDB7rq0 HIV integrase-LEDGF interaction screening by fragment linking using off-rate screening
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6I2 A Q95 E96 A98 Y99 L102 T125 A128 A129 A169 E170 H171 T174 Q37 E38 A40 Y41 L44 T67 A70 A71 A102 E103 H104 T107
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:7rq0, PDBe:7rq0, PDBj:7rq0
PDBsum7rq0
PubMed
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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