Structure of PDB 7ros Chain A

Receptor sequence
>7rosA (length=346) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
EESKIEDVDKILNDILSISSECIQPDELRVKLLLKRKLICYDGFEPSGRM
HIAQGLLKSIIVNKLTSNGCTFIFWIADWFAHLNNKMSGDLKKIKKVGSY
FIEVWKSCGMNMENVQFLWASEEINKKPNEYWSLVLDISRSFNINRMKRC
LKIMGRSEGEENYCSQILYPCMQCADIFFLNVDICQLGIDQRKVNMLARE
YCDIKKIKKKPVILSHGMLPGLLEGQEKSAIFMDDSESDVNRKIKKAYCP
PNVIENNPIYAYAKSIIFPSYNEFNLVRKEKNGGDKTYYTLQELEHDYVN
GFIHPLDLKDNVAMYINKLLQPVRDHFQNNIEAKNLLNEIKKYKVT
3D structure
PDB7ros Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 66I A Y60 D61 G62 F63 E64 A72 Q73 W94 F99 I172 Y188 Q192 D195 L206 G207 D209 Q210 M237 L238 K247 Y41 D42 G43 F44 E45 A53 Q54 W75 F80 I153 Y169 Q173 D176 L187 G188 D190 Q191 M218 L219 K228
BS02 MG A M131 V134 M112 V115
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046789 host cell surface receptor binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation
GO:0044650 adhesion of symbiont to host cell
Cellular Component
GO:0005737 cytoplasm
GO:0044164 host cell cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ros, PDBe:7ros, PDBj:7ros
PDBsum7ros
PubMed35653481
UniProtQ8IAR7

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