Structure of PDB 7rn6 Chain A

Receptor sequence
>7rn6A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
GAFARDPTQFEERHLKFLQQLGKGSVEMCRYDPLDNTGEVVAVKKLQHST
EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLR
DYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENEN
RVKIGDFGLTESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYISKS
PPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECW
NNNVNQRPSFRDLALRVDQIRDNM
3D structure
PDB7rn6 High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to type-II inhibitor BBT594
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 046 A L855 V863 A880 K882 E898 L902 L927 Y931 L932 G935 I973 H974 L983 G993 D994 F995 L21 V26 A42 K44 E60 L64 L89 Y93 L94 G97 I135 H136 L145 G155 D156 F157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7rn6, PDBe:7rn6, PDBj:7rn6
PDBsum7rn6
PubMed
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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