Structure of PDB 7rm6 Chain A

Receptor sequence

>7rm6A (length=374) Species: 9796 (Equus caballus)

STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDD
HVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKC
RVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYT
VVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGL
GGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPI
QEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQN
LSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVL
PFEKINEGFDLLRSGESIRTILTF

3D structure

• PDB: 7rm6 A two-directional vibrational probe reveals different electric field orientations in solution and an enzyme active site.
• Chain: A
• Resolution: 1.43 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.1: alcohol dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C46 H67 C174	C46 H67 C174
BS02	ZN	A	C97 C100 C103 C111	C97 C100 C103 C111
BS03	NAI	A	C46 R47 S48 H51 C174 T178 G201 V203 D223 I224 I269 V292 V294 I318	C46 R47 S48 H51 C174 T178 G201 V203 D223 I224 I269 V292 V294 I318
BS04	CXF	A	S48 L57 H67 F93 L116 C174 V294	S48 L57 H67 F93 L116 C174 V294

Gene Ontology

Molecular Function

• GO:0004022 alcohol dehydrogenase (NAD+) activity
• GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
• GO:0008270 zinc ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0042572 retinol metabolic process
• GO:0042573 retinoic acid metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7rm6, PDBe:7rm6, PDBj:7rm6
• PDBsum: 7rm6
• PubMed: 35513508
• UniProt: P00327|ADH1E_HORSE Alcohol dehydrogenase E chain