Structure of PDB 7rlu Chain A

Receptor sequence
>7rluA (length=583) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SLELTEAELATAEAVRSSWMRILPNVPEVEDSTDFFKSGAASVDVVRLVE
EVKELCDGLELENEDVYMATTFRGFIQLLVRKLRGVINYVEKAVNKLTLQ
MPYQLFIGGEFVDAEGSKTYNTINPTDGSVICQVSLAQVSDVDKAVAAAK
EAFENGLWGKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVYTLAL
KTHVGMSIQTFRYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVCGI
VIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIP
KGVVNILPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCALSNVKK
VSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEESI
HNQFVQKVVEEVEKMKIGNPLERDTNHGPQNHEAHLRKLVEYCQRGVKEG
ATLVCGGNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGD
VDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFINTYNKTDVA
APFGGFKQSGFGKDLGEAALNEYLRIKTVTFEY
3D structure
PDB7rlu Structure of putative tumor suppressor ALDH1L1.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.6: formyltetrahydrofolate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A K597 S629 G630 G634 G650 S651 V654 K278 S310 G311 G315 G331 S332 V335
BS02 PNS A K520 F701 N706 C707 N864 K201 F382 N387 C388 N545
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0016155 formyltetrahydrofolate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0033721 aldehyde dehydrogenase (NADP+) activity
GO:0044877 protein-containing complex binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0006740 NADPH regeneration
GO:0009058 biosynthetic process
GO:0009258 10-formyltetrahydrofolate catabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rlu, PDBe:7rlu, PDBj:7rlu
PDBsum7rlu
PubMed35013550
UniProtP28037|AL1L1_RAT Cytosolic 10-formyltetrahydrofolate dehydrogenase (Gene Name=Aldh1l1)

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