Structure of PDB 7rke Chain A

Receptor sequence
>7rkeA (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLTADQMVSALLDAEPPILYSFSEASMMGLLTNLADRELVHMINWAKRV
PGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQ
GMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTLEEKDHIHR
VLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYS
MKCKNVVPLSDLLLEMLDAH
3D structure
PDB7rke A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3- d ]pyrimidine Core.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 L539 E542 I44 K48 L58 V62 L212 E215
BS02 5VP A M343 L349 A350 E353 M421 I424 F425 H524 L525 M29 L35 A36 E39 M102 I105 F106 H197 L198
External links
PDB RCSB:7rke, PDBe:7rke, PDBj:7rke
PDBsum7rke
PubMed35859859
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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