Structure of PDB 7rk5 Chain A

Receptor sequence
>7rk5A (length=489) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
APLKLNSRNLSQIAAAGGALVKIPTYQRGRAVKEGIVHIGVGGFHRAHLA
VYIDQLMQKHGVNDYAICGVGLQPFDSAMRDALASQDHLYTLIERSAKGS
FAHVIGSINSYLFAPDNREAVIAKMAHPDTKIVSLTITESGYYYNENTHE
LQSNEKAPRTTFGFLYAGLTRRYQQGLKPFTVMSCDNMQKNGSITRHMLE
SFARLRNPEVAEWIAEEGAFPNAMVDRITPQTSETDKTALAEKFGIVDSW
PVVTEPFTQWVIEDQFSDGRPPFEKVGVQVVKDVHAVEQFEKHKLRLLNG
SHSALGYPGQLAGFQYVHEVMANPLFRKFVWQMMQEEVKPLLPEIPGVDI
DEYCNTLIERFTNPTIMDQLPRICLNASGKIPQFIMPSIAEAIWETGPFR
RLCFVAAAWFHYIKGVDDRGKPFEVVDPMREELQAKARAGGNDPSELLSI
KSLFGDDLRNDERFLREITTAMNDIARDGIMKTLPKYIN
3D structure
PDB7rk5 Targeting the Mannitol Biosynthesis Pathway in Aspergillus fumigatus: Characterisation and Inhibition of Mannitol-2-Dehydrogenase
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.67: mannitol 2-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI A V42 G43 G44 F45 D77 T137 I138 T139 D199 N200 R240 I241 T242 V41 G42 G43 F44 D76 T136 I137 T138 D186 N187 R227 I228 T229
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0046029 mannitol dehydrogenase activity
GO:0050086 mannitol 2-dehydrogenase activity
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0019594 mannitol metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7rk5, PDBe:7rk5, PDBj:7rk5
PDBsum7rk5
PubMed
UniProtQ4WQY4|M2DH_ASPFU Mannitol 2-dehydrogenase (Gene Name=AFUA_4G14450)

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