Structure of PDB 7rj8 Chain A

Receptor sequence
>7rj8A (length=297) Species: 10090 (Mus musculus) [Search protein sequence]
GYIGRVFGIGRQQVTVDEVLAEGGFALVFLVRTSNGVKCALKRMFVNNEH
DLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGG
QVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENI
LLHDRGHYVLCDFGSATNKFQNPQAEGVNAVEDEIKKYTTLSYRAPEMVN
LYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGSFTIPDNSRY
SQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPVPNVQNSPI
3D structure
PDB7rj8 Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
ChainA
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5QI A A53 V60 A72 V104 F128 C129 L183 C193 D194 A21 V28 A40 V72 F96 C97 L151 C161 D162
BS02 YFV A V38 Q45 V6 Q13
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7rj8, PDBe:7rj8, PDBj:7rj8
PDBsum7rj8
PubMed35171586
UniProtQ3UHJ0|AAK1_MOUSE AP2-associated protein kinase 1 (Gene Name=Aak1)

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