Structure of PDB 7rgi Chain A

Receptor sequence

>7rgiA (length=357) Species: 9606 (Homo sapiens)

GYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKF
EQGFITDPIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDL
LTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKN
LIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPII
ADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPKIAQGVSGSIQDKGS
IQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAQIEGG
VHGLHSY

3D structure

• PDB: 7rgi IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
• Chain: A
• Resolution: 3.6 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	P69 T252 R253 D274 S275 S276 Y282 R322	P59 T140 R141 D162 S163 S164 Y170 R210
BS02	IMP	A	G328 C331 D364 G365 G387 S388	G216 C219 D252 G253 G275 S276
BS03	NAD	A	I45 Q469	I35 Q317

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0003824 catalytic activity
• GO:0003938 IMP dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006177 GMP biosynthetic process
• GO:0006183 GTP biosynthetic process

Cellular Component

• GO:0005576 extracellular region
• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0034774 secretory granule lumen
• GO:0035578 azurophil granule lumen
• GO:1904813 ficolin-1-rich granule lumen

External links

• PDB: RCSB:7rgi, PDBe:7rgi, PDBj:7rgi
• PDBsum: 7rgi
• PubMed: 35013599
• UniProt: P20839|IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (Gene Name=IMPDH1)