Structure of PDB 7rgf Chain A

Receptor sequence

>7rgfA (length=418) Species: 10090 (Mus musculus)

QIRYPVPEESQEGTFVGNVAQDFLLDTESLSARRLQVAGEVNQRHFRVDL
DSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDH
APRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFA
LDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELR
VSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTF
SFSGHTPDRVRNLFSLHPTTGKLTLQGPLDFESENYYEFDVRARDGGSPA
MEQHCSLRVDLLDVNDNAPHITVTSELGTLPESAEPGTVVALISVQDPDS
GSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREARSSYDIMVTASD
AGNPPLSTHRTIFLNISD

3D structure

• PDB: 7rgf How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition.
• Chain: A
• Resolution: 2.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MAN	A	Q107 T196 E198	Q107 T196 E198
BS02	CA	A	E8 E9 D62 E64 D99	E8 E9 D62 E64 D99
BS03	CA	A	E8 E64 D96 V97 D99 D132	E8 E64 D96 V97 D99 D132
BS04	CA	A	N98 H100 D130 D132 N136 D187	N98 H100 D130 D132 N136 D187
BS05	CA	A	E115 D172 E174 D208	E115 D172 E174 D208
BS06	CA	A	E115 E174 D205 V206 D208 D241	E115 E174 D205 V206 D208 D241
BS07	CA	A	N207 N209 D239 D241 S245 D295	N207 N209 D239 D241 S245 D295
BS08	CA	A	E224 D280 E282 D316	E224 D280 E282 D316
BS09	CA	A	E224 E282 D313 V314 D316 D349	E224 E282 D313 V314 D316 D349
BS10	CA	A	N315 N317 D347 D349 N353 D400	N315 N317 D347 D349 N353 D400

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7rgf, PDBe:7rgf, PDBj:7rgf
• PDBsum: 7rgf
• PubMed: 35253643
• UniProt: Q91XX0