Structure of PDB 7rgd Chain A

Receptor sequence

>7rgdA (length=519) Species: 9606 (Homo sapiens)

GHETAAQRYSARLLQAGYMADYLISGGTGYVPEDGLTAQQLFASADGLTY
NDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAM
ALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLE
AKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPR
IELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRD
YPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVY
QIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICI
TQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGAS
TVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMKVKIAQGVSGSI
QDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSA
QIEGGVHGLHSYTFLPFTK

3D structure

• PDB: 7rgd IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
• Chain: A
• Resolution: 3.0 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GTP	A	K109 P118 F139 S140 G141 K208 T225 D226	K127 P136 F157 S158 G159 K226 T243 D244
BS02	GTP	A	E111 Q112 N198 D226 L227 N230 K238 K242	E129 Q130 N216 D244 L245 N248 K256 K260
BS03	ATP	A	T159 S160 R161 D162 L185 V186 K206 G207	T177 S178 R179 D180 L203 V204 K224 G225
BS04	IMP	A	S68 M70 G328 S329 I330 C331 D364 G365 G387 S388 Y411 G413 M414 G415 Q441 G442	S86 M88 G346 S347 I348 C349 D382 G383 G405 S406 Y429 G431 M432 G433 Q444 G445
BS05	NAD	A	T252 R253 D274 S275 S276 Y282 N303 M325 T333 M414 Q441	T270 R271 D292 S293 S294 Y300 N321 M343 T351 M432 Q444

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003824 catalytic activity
• GO:0003938 IMP dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006177 GMP biosynthetic process

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:7rgd, PDBe:7rgd, PDBj:7rgd
• PDBsum: 7rgd
• PubMed: 35013599
• UniProt: Q5H9Q6