Structure of PDB 7rg5 Chain A

Receptor sequence
>7rg5A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence]
SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVH
CLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ
NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVT
WVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD
AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV
VLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP
MIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLT
VKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENE
DIYKLAYEIIDQFFSS
3D structure
PDB7rg5 MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R96 S100 D102 R103 W137 N141 S144 G145 T146 T150 Q176 W179 N183 G186 W222 N226 R229 R25 S29 D31 R32 W66 N70 S73 G74 T75 T79 Q105 W108 N112 G115 W151 N155 R158
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rg5, PDBe:7rg5, PDBj:7rg5
PDBsum7rg5
PubMed35338144
UniProtO00629|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)

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