Structure of PDB 7rep Chain A

Receptor sequence
>7repA (length=764) Species: 580 (Kluyvera cryocrescens) [Search protein sequence]
SNMWVIGKNKAQDAKAIMVNGPQFGWYVPAYTYGIGLHGAGYDVTGNTPF
AYPGIVFGHNGTISWGSTAGGGDDVDIFAEKLSAEKPGYYQHNGEWVKML
SRKETIAVKDGQPETFTVWRTLHGNVIWTDTATQTAYAKARAWDGKEVAS
LLAWTHQMKAKNWPEWTQQAAKQALTINWYYADVNGNIGYVHTGAYPDRQ
PGHDPRLPVPGTGKWDWKGLLSFDLNPKVYNPQSGYIANWNNSPQKDYPA
SDSFPFLWGGADRVTEIDTILDKQPRFTADQAWDVIRQTSRRDLNLRLFL
PALKDATANLAENDPRRQLVDKLASWDGENLVNDDGKTYQQPGSAILDAW
LTSMLKRTVVAAVPAPFGKWYSASGYETTPDGPTGSLNISVGAKILYEAL
QGDKSPIPQAVDLFGGKPQQEVILAALDDAWQTLSKRYGNDVDSWKTPAM
ALTWRANNFFGVPQAAAKEARPQAEYQNRGTENDMIVFSPTSGNRPVLAW
DVVAPGQSGFIAPDGKKDKHYDDQLKMYESFGRKSLWLTPQDVDEHQESQ
EVLQVQLDQGEVKIVRDEYGMPHIYADDTYRLFYGYGYVVAQDRLFQMEM
ARRSTQGTVSEVLGKAFVSFDKDIRQNYWPDSIRAQIASLSAEDKSILQG
YADGMNAWIDKVNASPDKLLPQQFSTFGFKPKHWEPFDVAMIFVGTMANR
WSDSTSEIDNLALLTALKDKYGKQQGMAVFNQLKWLVNPSAPTTIAARES
AYPLKFDLQNTQTA
3D structure
PDB7rep A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins.
ChainA
Resolution2.192 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.11: penicillin amidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D73 V75 D76 P205 D252 E707 D73 V75 D76 P205 D252 E707
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Biological Process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7rep, PDBe:7rep, PDBj:7rep
PDBsum7rep
PubMed35709255
UniProtP07941|PAC_KLUCR Penicillin G acylase (Gene Name=pac)

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