Structure of PDB 7rei Chain A

Receptor sequence
>7reiA (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
RDNMASLIQRIARQASLTFREAPMQPGFPENLSKLKSLLTQLRAEDLNIA
PRKATLQPLPPNLPPVTYMHIYETDGFSLGVFLLKSGTSIPLHDHPGMHG
MLKVLYGTVRISCMDKLDAGGGQRPRALPPEQQFEPPLQPREREAVRPGV
LRSRAEYTEASGPCILTPHRDNLHQIDAVEGPAAFLDILAPPYDPDDGRD
CHYYRVLEPVRSDLPREVWLLETPQADDFWCEGEPYPGPKVFP
3D structure
PDB7rei Crystal structure of human cysteamine dioxygenase provides a structural rationale for its function as an oxygen sensor.
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.19: cysteamine dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NI A H112 H114 H193 H93 H95 H174
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
GO:0047800 cysteamine dioxygenase activity
GO:0051213 dioxygenase activity
Biological Process
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:7rei, PDBe:7rei, PDBj:7rei
PDBsum7rei
PubMed34508780
UniProtQ96SZ5|AEDO_HUMAN 2-aminoethanethiol dioxygenase (Gene Name=ADO)

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