Structure of PDB 7ree Chain A

Receptor sequence
>7reeA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
AFARDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDGEVVAVKKLQHS
TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSL
RDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE
NRVKIGDFGLTKVLPQDKEYYKVKEPSPIFWYAPESLTESKFSVASDVWS
FGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLP
RPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNM
3D structure
PDB7ree High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to YM2-059.
ChainA
Resolution1.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4LY A L855 G856 K857 G858 V863 A880 M929 E930 Y931 L932 G935 R980 N981 L983 G993 D994 L20 G21 K22 G23 V28 A43 M92 E93 Y94 L95 G98 R143 N144 L146 G156 D157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ree, PDBe:7ree, PDBj:7ree
PDBsum7ree
PubMed
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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