Structure of PDB 7rd6 Chain A

Receptor sequence
>7rd6A (length=929) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
EREIHPDTTPVYDRNRYVSNELSNAKYNAVTFVPTLLYEQFKFFYNLYFL
VVALSQAVPALRIGYLSSYIVPLAFVLTVTMAKEAIDDIQRRRRDRESNN
ELYHVITRNRSIPSKDLKVGDLIKVHKGDRIPADLVLLQSSEPSGESFIK
TDQLDGETDWKLRVACPLTQNLINRISITASAPEKSIHKFLGKVTYKDST
SNPLSVDNTLWANTVLASSGFCIACVVYTGRDTRQAMNTTTAKVKTGLLE
LEINSISKILCACVFALSILLVAFAGFHNDDWYIDILRYLILFSTIIPVS
LRVNLDLAKSVYAHQIEHDKTIPETIVRTSTIPEDLGRIEYLLSDKTGTL
TQNDMQLKKIHLGTVSYTSETLDIVSDYVQSLVKDMSFRVRDMILTLAIC
HNVTPTFEDDELTYQAASPDEIAIVKFTESVGLSLFKRDRHSISLLHEHS
GKTLNYEILQVFPFNSDSKRMGIIVRDEQLDEYWFMQKGADTVMSKIVES
NDWLEEETGNMAREGLRTLVIGRKKLNKKIYEQFQKEITKYLEHDLELLG
LTGVEDKLQKDVKSSIELLRNAGIKIWMLTGDKVETARCVSISAKLISRG
QYVHTITKVACLLIDGESLGMFLKHYEQEFFDVVVHLPTVIACRCTPQQK
ADVALVIRKMTGKRVCCIGDGGNDVSMIQCADVGVGIVGKEGKQASLAAD
FSITQFCHLTELLLWHGRNSYKRSAKLAQFVMHRGLIIAICQAVYSICSL
FEPIALYQGWLMVGYATCYTMAPVFSLTLDHDIEESLTKIYPELYKELTE
GKSLSYKTFFVWVLLSLFQGSVIQLFSQAFTSLLDTDFTRMVAISFTALV
VNELIMVALEIYTWNKTMLVTEIATLLFYIVSVPFLGDYFDLGYMTTVNY
YAGLLVILLISIFPVWTAKAIYRRLHPPS
3D structure
PDB7rd6 Structural basis of the P4B ATPase lipid flippase activity.
ChainA
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BEF A L773 T774 K862 N885 L579 T580 K650 N673
BS02 MG A D882 N885 D670 N673
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140346 phosphatidylserine flippase activity
GO:0180013 lysophosphatidylserine flippase activity
Biological Process
GO:0006869 lipid transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0006897 endocytosis
GO:0007033 vacuole organization
GO:0015031 protein transport
GO:0015914 phospholipid transport
GO:0045332 phospholipid translocation
GO:0098629 trans-Golgi network membrane organization
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0000139 Golgi membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7rd6, PDBe:7rd6, PDBj:7rd6
PDBsum7rd6
PubMed34645814
UniProtP40527|ATC7_YEAST Phospholipid-transporting ATPase NEO1 (Gene Name=NEO1)

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