Structure of PDB 7rcw Chain A

Receptor sequence
>7rcwA (length=822) Species: 645463 (Clostridioides difficile R20291) [Search protein sequence]
KLAIEAPRGEIKDRYGRLLAGNKNLFTVQVSGNDINKKDANKHSRANEIS
LKLINLLERNGEEYVDEFPIYVENGKYYYTYDRDIREYKSENGIPNDYNA
KESFYYLVDKLISAGILSQEDKRLDATRLQAKLNENGYYPPILVSKWMFT
AERDKRDWLASYKIKETKLSAKEAFEKVRNSDALEIDKSLSDEDARKIMV
VRDLIKSKGYSQYNPVTIAKDVGETTIAQIEESAMDLVGVSIAVEPVRYY
PNGSLASHMLGYVGKMPSTQIESYLQKGYETGDMVGLAGVEKSNESRLRG
TDGYKMVKSKKPKSGDTVYLTLDKDLQEVSDNALKQIIEVASKGGTFKSK
FGDKPISAYAGKAQSAALIAIDVKNGEVLASSSYPNYDPNKFAKGISTED
YKALQPKNPNDLLAGSPLLNLVTQGEFQPGSSFKMLTSMAALENGLDPNF
TINDPGVIMLGKKSFGDYVWNHGRGNHGMTNLYKAIQESCNIYMATIGTG
KTWPDGKSIGIDMNANKILEYAKLFGLDQNTGLQDEVEERAGKVPSTEDK
LKSAKWSTADTFNLAIGQGENAYTPAQISRYVAAIANGGNLVELSVVDRA
VSSDYSSVKINDQKKVEKIPFKNPDNLKELTKGMKLVARQGTAKSAFADF
PIDVAAKTGTAEKSGKIPTDNEYEYLKSHMSSYNVNLNDAIKLADKMKAE
KEKELSLAKEKEIKKKLENKDLKDEERKKLEEELEDGVKVRLEDTDKVNS
SYLRKAIKELNPKITDDQIDRFKQDYGSFTWTVAFAPADDPEIAVVCVIP
QGDSSVFSLLPTREVIGTYMGL
3D structure
PDB7rcw A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.129: Transferred entry: 2.4.99.28.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZZ7 A S492 Y529 S550 N552 Q708 T798 G799 T800 S431 Y468 S489 N491 Q568 T658 G659 T660
BS02 ZN A D515 D528 H538 C551 D454 D467 H477 C490
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0071555 cell wall organization
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rcw, PDBe:7rcw, PDBj:7rcw
PDBsum7rcw
PubMed35902581
UniProtQ18B08

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