Structure of PDB 7rav Chain A

Receptor sequence
>7ravA (length=773) Species: 10090 (Mus musculus) [Search protein sequence]
MKMKKGFNSQMRSEAKRLKTFETYDTFRSWTPQEMAAAGFYHTGVRLGVQ
CFCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVGNIGKYDIRVKRPE
KMLRGGKARYHEEEARLESFEDWPFYAHGTSPRVLSAAGFVFTGKRDTVQ
CFSCGGSLGNWEEGDDPWKEHAKWFPKCEFLQSKKSSEEIAQYIQSYEGF
VHVTGEHFVKSWVRRELPMVSAYCNDSVFANEELRMDMFKGVEALVRAGF
FYTGKKDIVRCFSCGGCLEKWAEGDDPMEDHIKFFPECVFLQTLKSARSL
SEQLRDNYTKATFRHMNLPEVCSSLGTDHLLSCDVSIISKHISQPVQEAL
TIPEVFSNLNSVMCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFY
LSLSSITPDQGLANIICAQLLGAGGCISEVCLSSSIQQLQHQVLFLLDDY
SGLASLPQALHTLITKNYLSRTCLLIAVHTNRVRDIRLYLGTSLEIQEFP
FYNTVSVLRKFFSHDIICVEKLIIYFIDNKDLQGVYKTPLFVAAVCTDWI
QNASAQDKFQDVTLFQSYMQYLSLKYKATAEPLQATVSSCGQLALTGLFS
SCFEFNSDDLAEAGVDEDEKLTTLLMSKFTAQRLRPVYRFLGPLFQEFLA
AVRLTELLSSDRQEDQDLGLYYLRQIDSPLKAINSFNIFLYYVSSHSSSK
AAPTVVSHLLQLVDSSFVSEHLLRLALIFAYESNTVAECSPFILQFLRGK
TLALRVLNLQYFRDHPESLLLLR
3D structure
PDB7rav Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5.
ChainA
Resolution3.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A C425 C436 G473 S474 G475 K476 T477 T478 R482 D551 D552 V610 P642 C322 C333 G370 S371 G372 K373 T374 T375 R379 D448 D449 V507 P539
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0016045 detection of bacterium
GO:0032731 positive regulation of interleukin-1 beta production
GO:0042742 defense response to bacterium
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response
GO:0046718 symbiont entry into host cell
GO:0050829 defense response to Gram-negative bacterium
GO:0070269 pyroptotic inflammatory response
Cellular Component
GO:0072557 IPAF inflammasome complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7rav, PDBe:7rav, PDBj:7rav
PDBsum7rav
PubMed36604500
UniProtQ9R016|BIR1E_MOUSE Baculoviral IAP repeat-containing protein 1e (Gene Name=Naip5)

[Back to BioLiP]