Structure of PDB 7r9y Chain A

Receptor sequence

>7r9yA (length=853) Species: 9606 (Homo sapiens)

NREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDL
NSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQK
YTLKINHDCVPEQVIAEAIRKKTRSQGKYILKVCGCDEYFLEKYPLSQYK
YIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRKSLWVINSALRI
KILCATYVNIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIP
DLPRAARLCLSICSVKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPH
GLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSL
RENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVK
WNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYL
TDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKS
EMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEK
KDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMS
SAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENI
WQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFN
SHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMV
KDDGQLFHIDFGHFLDPFVLTQDFLIVISTKTREFERFQEMCYKAYLAIR
QHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQ
MND

3D structure

• PDB: 7r9y Covalent Proximity Scanning of a Distal Cysteine to Target PI3K alpha.
• Chain: A
• Resolution: 2.85 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.
  2.7.1.137: phosphatidylinositol 3-kinase.
  2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	2IX	A	M772 I800 K802 D810 I848 V850 V851 C862 I932 D933	M599 I627 K629 D637 I675 V677 V678 C689 I759 D760

Gene Ontology

Molecular Function

• GO:0016301 kinase activity

Biological Process

• GO:0046854 phosphatidylinositol phosphate biosynthetic process

External links

• PDB: RCSB:7r9y, PDBe:7r9y, PDBj:7r9y
• PDBsum: 7r9y
• PubMed: 35353516
• UniProt: P42336|PK3CA_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Gene Name=PIK3CA)