Structure of PDB 7r9f Chain A

Receptor sequence
>7r9fA (length=379) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
LPKRKVAVMVGYCGTGYHGMQYNPPNPTIESALFKAFVEAGAISKDNSFM
RAARTDKGVHAGGNLISLKMIIEDPDIKQKINEKLPEGIRVWDIERVNKA
FDCRKMCSSRWYEYLLPTYSLIGPKPGSILYRDIEESKTELLDEDLESKE
FWEEFKKDANEKFSTEEIEAILEELYQKVKKYKQLENAHRRRYRISAAKL
AKFRASTSQYLGAHNFHNFTLGKDFKEPSAIRFMKDIKVSDPFVIGDAQT
EWISIKIHGQSFMLHQIRKMVSMATLITRCGCPVERISQAYGQQKINIPK
APALGLLLEAPVFEGYNKRLEQFGYKAIDFSKYQDEVDKFKMKHIYDKIY
KEEVDENVFNAFFSYIDSFKSIFEFLTAK
3D structure
PDB7r9f Wild-type yeast Pseudouridine Synthase bound to 5-Fluorouracil RNA
ChainA
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.4.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A H89 Q92 N94 N97 R132 D134 K135 Y459 H18 Q21 N23 N26 R54 D56 K57 Y365
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0008270 zinc ion binding
GO:0009982 pseudouridine synthase activity
GO:0016853 isomerase activity
GO:0106029 tRNA pseudouridine synthase activity
GO:0106032 snRNA pseudouridine synthase activity
Biological Process
GO:0001522 pseudouridine synthesis
GO:0006397 mRNA processing
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0009451 RNA modification
GO:0031119 tRNA pseudouridine synthesis
GO:0031120 snRNA pseudouridine synthesis
GO:1990481 mRNA pseudouridine synthesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r9f, PDBe:7r9f, PDBj:7r9f
PDBsum7r9f
PubMed37939088
UniProtQ12211|PUS1_YEAST tRNA pseudouridine synthase 1 (Gene Name=PUS1)

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