Structure of PDB 7r8h Chain A

Receptor sequence

>7r8hA (length=769) Species: 2029104 (Pseudooceanicola lipolyticus)

MTLETTLFPLEGTGACGASYQLYAVKGLSGLDETEYHKNVNLLVRRLSFS
MKAPFVALSRDGEQFIAVPNYVTEFPVDHRVVRAMVKLVPTGEPLNLRFD
AADDEYDGLRLRYLDFVLQQPLFANHHLWQPGSGQPFFHKKPLKRLDDVD
LYDGVSVRAAKHPEGGFGIVCDARSKFITHTPIGARADRKRLGKLINRSC
LYKMGDHWYQFRIDAVSDWKVGEPSLFEGNVPISLAQQLVRTAGNAAPKS
IIDLDPEGGALEYFTSTNERRMAPAELCFLIEDTHGRRAAKLQRQTILSP
SERRARVNGFIRRYLSELNIGGAKLSAGARAHAFFTETHMPPALSFGNGT
VLAPDTSKDRFQAMQEYSSMRRTMMLDKKVGFFHQDVFPPQTLLLPESVK
KSWGPAFASDFVGTVQELYPAGGYRPEIIEYRDKAYGGGVPGQMKALLEV
AERGEIKSGDVLVMLHRINGAPRAQDKLAAMVCNEFEKRFGKRVQVIHSD
SPGRGYKRIFKNDKPTYVQQRGRGVNIKGYLKGAALNKVCLGNSRWPFVL
RDPLNADVTIGIDVKNNMAVFTMVAEGGRIVRVQRSRSRQREQLLESQVT
QVITEMLSKELPEIKKQVQRVVIHRDGRAWPAEIAGARKTFADMAESGLI
AVDADVSVFEVLKSSPAPLRLFSFEEPTQENPKGVINPVLGSWLKLSEND
GYICTTGAPLLLQGTADPLHVRKAFGPMAIEDALKDVFDLSCLTWPKPDS
CMRLPLTIKLCDIALFDDA

3D structure

• PDB: 7r8h Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity.
• Chain: A
• Resolution: 2.54 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R45 F49 K52 R112 F116 Q120 F123 S133 R174 S175 K176 Y202 Y209 R212 L226 L239 S266 R271 M272 D283 H285 T296 L298 R303 R473 I497 H498 S501 Y530 N537 K538 R591 R628 R670 T706 Q713 T715 D717 K747 S750 C751 R753 K759	R45 F49 K52 R112 F116 Q120 F123 S133 R174 S175 K176 Y202 Y209 R212 L226 L239 S266 R271 M272 D283 H285 T296 L298 R303 R473 I497 H498 S501 Y530 N537 K538 R591 R628 R670 T706 Q713 T715 D717 K747 S750 C751 R753 K759

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding

External links

• PDB: RCSB:7r8h, PDBe:7r8h, PDBj:7r8h
• PDBsum: 7r8h
• PubMed: 35941106
• UniProt: A0A2M8J4C7