Structure of PDB 7r8b Chain A

Receptor sequence
>7r8bA (length=588) Species: 9606 (Homo sapiens) [Search protein sequence]
PHSLGILHASYSVRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGR
LGRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTA
LLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNYSLGGISTGERRRVS
IAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQP
RSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYM
DLTSVDTQSKEREIETSKRVQMIESAYKKSAICHKTLKNIERMKHLKTLP
MVPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLF
FVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQE
SQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYF
SAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNI
QEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGNPMCFTQGIQFIEK
TCPGATSRFTMNFLILYSFIPALVILGIVVFKIRDHLI
3D structure
PDB7r8b Molecular basis of cholesterol efflux via ABCG subfamily transporters.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A M396 Y432 M344 Y380
BS02 CLR A N528 I529 N476 I477
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0120020 cholesterol transfer activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006869 lipid transport
GO:0007584 response to nutrient
GO:0009410 response to xenobiotic stimulus
GO:0010212 response to ionizing radiation
GO:0010949 negative regulation of intestinal phytosterol absorption
GO:0014850 response to muscle activity
GO:0015918 sterol transport
GO:0030299 intestinal cholesterol absorption
GO:0031667 response to nutrient levels
GO:0033344 cholesterol efflux
GO:0042632 cholesterol homeostasis
GO:0045796 negative regulation of intestinal cholesterol absorption
GO:0055085 transmembrane transport
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0043235 receptor complex
GO:0045177 apical part of cell

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r8b, PDBe:7r8b, PDBj:7r8b
PDBsum7r8b
PubMed34404721
UniProtQ9H222|ABCG5_HUMAN ATP-binding cassette sub-family G member 5 (Gene Name=ABCG5)

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