Structure of PDB 7r78 Chain A

Receptor sequence
>7r78A (length=1880) Species: 235443 (Cryptococcus neoformans var. grubii H99) [Search protein sequence]
DDLPPISDIEAMFDHLVSRIPDIVELVRQLNGRKLRVATMCSGTESPLLA
LNMIAKAIKAQHGLTLAFEHVFSCEIEPFKQAYIERNFTPPILFRDVTEL
GKKRAHTAYGSMVDVPGDVDILIAGTSCVDYSNLNNVQQDIDANGESGRT
FRGMLQWVKKHQPPIVILENVCNAPWDKVVEYFGQIDYDAQYTRLDTKEF
YIPHTRTRVYLFATPSSSESDDLPEKWAQTVKDLRRPWSSPFEAFLLHTD
DPNIHRARLELASARAGTSRKTTDWNRCESRHQRARQDEALGLLRPLTSW
QEAGVCKGLDWTWNDWLLAQTERVVDLLEISTLRMAKDGIDSGFKACIWN
VSQNVDRQTGSSKTALAPCLTPNMIPWVTIRGGPVTGREALALQGIPVRE
LLLTSENEDQLADLAGNAMTTTVVGSAMIAALKVACHKITEGANPEKEAA
LILEKEAVDDEQVANRIIGEDYLEHHDLDLAKVTKSNLSEILDLACRSSR
HCQCEGQSGTAPNILECQECSYRACKSCGGRPEHVYAPCANQRVEPAEFE
KRFKGLLPMRVRIAGLTDQCLNAVRKAAEKSNKGSVNDNDWQLWSTALLE
GIHDAEFRFRYLKRQSTWTAVYEARRAMLSLVLRNQIPEWRLTIKAPASE
PNNSQLRALLLHPVARLQIDIAGQDVLCGPWELCIPSMKTIDIEITGKGE
LLPSWQASLGLQGPFANTTRWSEVEISLQAEDENTLDRKLSGTYQLLPRC
GQAMSSLHKKRPDLSDDGLPQLYFFLDPTRCGESREDRYVFSTSTERLDY
GTERPVIARLDSHWREGNEKQRKVKLDVSGAWVKCPEAHLTAIRATFAIP
SSASAISASLTTEGCSHAMALLSCRVPLDPTHSESMWRRGAWAEIDLSHQ
GNTTFANLAWITERLPPLDGLKNWAHIADDVSEHVCERCAPRPPKIHWIK
RAFEDKLEAGQYEHALKHRPSPFVVQLRLDQDIGSFRIGLNIVSLAHRAL
SRLPPTTSEHKISLSWRLTPGHVTESPQPRRVFILPSNKQDPENSQPEAF
KLPLRKEQLRSLWWMLEQEKATGKTHTFVEEEISESLLPAVGWRAEGKAE
RPVMVRGGVIADQVGYGKTVISIALVAQTLSLPAPEPATPGLIDLKATLI
VVPGHLSKQWPNEIARFTGSMFKVIVIQGMKDLQEKTIAELGKADIIVMA
SEIFESDVYWSRLEYLSAQPREWLHDTQGGRFFCDRLDAAMESLVSQTKI
LKEKGSEAAMRAMEDKKKSLVDNVGSKKEVHTKLLPNPVLHMFRFRRVIA
DEFTYLQKKSLAAVLRLSSSYRWILSGTPPVSDFAAIRSIATFMGIHLGV
EDDGEGDDQTQAEKFHAFREVHSRAWHNRRDELAQEFLNVFVRQNIAEIE
DIPTVEHIHTFKLPASEGAVYLELEHHLQALEMQARKENVSQGDRNARLE
EALSDSKTAEEALLKRCCHFTLDLSDKTQDAKSAQEACDHITSARARQLL
ACQEDLSRSVNQAIALHGWIKKKGGFSKNDDERQPFAEWIAFSSNISKHQ
GDIEAARILLKVIEKCGVKDGNIPPSPSDKQSPSIASGAKMDDVKWQLRE
QTHLLRKLVKELVARVRSLRFFEVVRKIQKGKSDAQIVLESSECGHKPST
NPDIEMAILSCCGHVACHKCMRKAAASQRCVKSGECQAAVRPTNIVKVSS
LGVEGELSSGRYGAKLEHLVNLIHSIPKNERVLVFLQWEDLAGKVSEALS
AGRIPHVTLSGSAKSRANTLDRFQSTNADSARVLLLKMNDASAAGSNLTT
ANHAVFLGPLFTNSLFNYRAVETQAIGRVRRYGQQKKVHIHRLLALDTID
MTIFNARRTELKEKTDWEEIPQEEYKGRGS
3D structure
PDB7r78 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0008168 methyltransferase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0043565 sequence-specific DNA binding
GO:0120328 ATP-dependent DNA (cytosine-5-)-methyltransferase activity
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006289 nucleotide-excision repair
GO:0006338 chromatin remodeling
GO:0006346 DNA methylation-dependent heterochromatin formation
GO:0009889 regulation of biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r78, PDBe:7r78, PDBj:7r78
PDBsum7r78
PubMed35202575
UniProtJ9VI03|DMT5_CRYNH DNA (cytosine-5-)-methyltransferase DMT5 (Gene Name=DMT5)

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