Structure of PDB 7r76 Chain A

Receptor sequence
>7r76A (length=1834) Species: 235443 (Cryptococcus neoformans var. grubii H99) [Search protein sequence]
LDIKAAVRNMSDDLPPISDIEAMFDHLVSRIPDIVELVRQLNGRKLRVAT
MCSGTESPLLALNMIAKAIKAQHGLTLAFEHVFSCEIEPFKQAYIERNFT
PPILFRDVTELGKKRAHTAYGSMVDVPGDVDILIAGTSCVDGESGRTFRG
MLQWVKKHQPPIVILENVCNAPWDKVVEYFGQIDYDAQYTRLDTKEFYIP
HTRTRVYLFATPSSSESDDLPEKWAQTVKDLRRPWSSPFEAFLLHTDDPN
IHRARLELASARAQTRKTTDWNRCESRHQRARQDEALGLLRPLTSWQEAG
VCKGLDWTWNDWLLAQTERVVDLLEISTLRMAKDGIDSGFKACIWNVSQN
VDRQTGSSKTALAPCLTPNMIPWVTIRGGPVTGREALALQGIPVRELLLT
SENEDQLADLAGNAMTTTVVGSAMIAALKVACHKITEGANPEKEAALILE
KEAVDDEQVANRIIGEDYLEHHDLDLAKVTKLSEILDLACRSSRHCQCEG
QSGTAPNILECQECSYRACKSCGGRPEHVYAPCANQRVEPAEFEKRFKGL
LPMRVRIAGLTDQCLNAVRKAAEKSNKGSVNDNDWQLWSTALLEGIHDAE
FRFRYLKRQSTWTAVYEARRAMLSLVLRNQIPEWRLTIKAPASEPNNSQL
RALLLHPVARLQIDIAGQDVLCGPWELCIPSMKTIDIEITGKGELLPSWQ
ASLGLQGPFANTTRWSEVEISLQAEDENTLDRKLSGTYQLLPRCGQAMSS
LHKKRPDLSDDGLPQLYFFLDPTRCGESREDRYVFSTSTERLDYGTERPV
IARLDSHWREGNEKQRKVKLDVSGAWVKCPEAHLTAIRATFAIPSSASAI
SASLTTEGCSHAMALLSCRVPLDPTHSESMWRRGAWAEIDLSHQGNTTFA
NLAWITERLPPLDGLKNWAHIADDVSEHVCERCAPRPPKIHWITIIAFED
KLEAGQYEHALKHRPSPFVVQLRLDQDIGSFRIGLNIVSLAHRALSRLPP
TTSEHKISLSWRLTPGHVTESPQPRRVFILPSNKQDPENSQPEAFKLPLR
KEQLRSLWWMLEQEKATGKTHTFVEEEISESLLPAVGWRAEGKAERPVMV
RGGVIADQVGYGKTVISIALVAQTLSLPAPEPATPGLIDLKATLIVVPGH
LSKQWPNEIARFTGSMFKVIVIQGMKDLQEKTIAELGKADIIVMASEIFE
SDVYWSRLEYLSAQPREWLHDTQGGRFFCDRLDAAMESLVSQTKILKLLP
NPVLHMFRFRRVIADEFTYLQKKSLAAVLRLSSSYRWILSGTPPVSDFAA
IRSIATFMGIHLGVEDDGEGDVQYQKARAKDQTQAEKFHAFREVHSRAWH
NRRDELAQEFLNVFVRQNIIEDIPTVEHIHTFKLPASEGAVYLELEHHLQ
ALEMQARKETKFKNVSQGDRNARLEEALSDSKTAEEALLKRCCHFTLDLS
DKTQDAKSAQEACDHITSARARQLLACQEDLSRSVNQAIALHGWIKKKGG
FSKNDDERQPFAEWIAFSSNISKHQGDIEAARILLKVIEKCGVKDGNIPP
SPSDKQSPSGAKMDDVKWQLREQTHLLRKLVKELVARVRSLRFFEVVRKI
QKGKSDAQIVLESSECGHKEMAILSCCGHVACHKCMRKAAASQRCVKSCQ
AAVRPTNIVKVSSLGVEGELSSGRYGAKLEHLVNLIHSIPKNERVLVFLQ
WEDLAGKVSEALSAGRIPHVTLSGSAKSRANTLDRFQSTSARVLLLKMND
GSNLTTANHAVFLGPLFTNSLFNYRAVETQAIGRVRRYGQQKKVHIHRLL
ALDTIDMTIFNARRTELKEKTDWEEIPQEEYKGR
3D structure
PDB7r76 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance.
ChainA
Resolution3.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1200 C1271 C1274 H1348 C859 C930 C933 H992
BS02 ZN A C832 H849 C1065 C511 H528 C744
BS03 ZN A L2096 C2099 H2101 L1624 C1627 H1629
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0008168 methyltransferase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0043565 sequence-specific DNA binding
GO:0120328 ATP-dependent DNA (cytosine-5-)-methyltransferase activity
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006289 nucleotide-excision repair
GO:0006338 chromatin remodeling
GO:0006346 DNA methylation-dependent heterochromatin formation
GO:0009889 regulation of biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7r76, PDBe:7r76, PDBj:7r76
PDBsum7r76
PubMed35202575
UniProtJ9VI03|DMT5_CRYNH DNA (cytosine-5-)-methyltransferase DMT5 (Gene Name=DMT5)

[Back to BioLiP]