Structure of PDB 7r55 Chain A

Receptor sequence

>7r55A (length=324) Species: 946362 (Salpingoeca rosetta) [Search protein sequence]

TFEPATDSPLPVPGVQYFLQHVQSGKYVHPHGGSDMPGNDTALVLHHGFD
EKRDALRWVFVNDAENKHQLKHYSSGKFVHPKGGKVGKEATLVVHSSPGR
PETMIEMVQEDGRTYLRHTDSDYYVHPHGGSPNPGDNTRLVYYSGYRPSL
AFLAIPAETLFVDRIEIHQAQALESINTITSLSDEHRNDTDQPVQTSISV
ALEESLQDSAQLSFERCFGLKVGSEFEVGLPLVGKTKVSVQFSGSWKSST
IKGEVRTSAVKVQINEHVTIPPGKCVQIRIDTRRCTKTAPATMYLRTASG
IEVQRETTVTSTYHYDQEVHVVPV

3D structure

PDB

7r55 The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3.

Chain

Resolution

1.84 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	A	K91 Y146	K88 Y143
BS02	GAL	A	E92 G132	E89 G129
BS03	GLA	A	E92 H129 H131 G132 G133 Y146 R150	E89 H126 H128 G129 G130 Y143 R147
BS04	GLC	A	N42 D43 H98	N39 D40 H95
BS05	GAL	A	D43 G86 H98	D40 G83 H95
BS06	GLA	A	D43 H83 K85 G86 G87 H98 S100 R103	D40 H80 K82 G83 G84 H95 S97 R100

External links

PDB	RCSB:7r55, PDBe:7r55, PDBj:7r55
PDBsum	7r55
PubMed	36097056
UniProt	F2UID9

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