Structure of PDB 7r4p Chain A

Receptor sequence
>7r4pA (length=337) Species: 9606 (Homo sapiens) [Search protein sequence]
PRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPR
MLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLG
TGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGY
KAIFVTVDTPYLGNRLDDVRNRFMKNFSGLAAYVAKAIDPSISWEDIKWL
RRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVL
PEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQG
EKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRK
3D structure
PDB7r4p Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide
ChainA
Resolution1.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.3.15: (S)-2-hydroxy-acid oxidase.
1.2.3.5: glyoxylate oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A Y27 A79 T80 A81 S108 Q130 Y132 T158 K236 H260 G261 R263 D291 G292 R295 G314 R315 Y25 A77 T78 A79 S106 Q128 Y130 T156 K211 H235 G236 R238 D266 G267 R270 G289 R290
BS02 I2Z A Y26 A81 M82 W110 Y132 R167 L205 H260 R263 Y24 A79 M80 W108 Y130 R165 L180 H235 R238
Gene Ontology
Molecular Function
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0047969 glyoxylate oxidase activity
Biological Process
GO:0001561 fatty acid alpha-oxidation
GO:0006545 glycine biosynthetic process
GO:0006979 response to oxidative stress
GO:0008652 amino acid biosynthetic process
GO:0046296 glycolate catabolic process
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle

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Cellular Component
External links
PDB RCSB:7r4p, PDBe:7r4p, PDBj:7r4p
PDBsum7r4p
PubMed
UniProtQ9UJM8|HAOX1_HUMAN 2-Hydroxyacid oxidase 1 (Gene Name=HAO1)

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