Structure of PDB 7r4o Chain A

Receptor sequence
>7r4oA (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
PRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPR
MLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLG
TGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGY
KAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNLAAYVAKAIDPSISWED
IKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPAT
IDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGL
AFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRK
3D structure
PDB7r4o Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.3.15: (S)-2-hydroxy-acid oxidase.
1.2.3.5: glyoxylate oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I2W A Y134 K135 D136 N185 K211 Y132 K133 D134 N183 K190
BS02 FMN A Y27 A79 T80 A81 S108 Q130 Y132 K236 H260 G261 R263 D291 G292 R295 G314 R315 Y25 A77 T78 A79 S106 Q128 Y130 K215 H239 G240 R242 D270 G271 R274 G293 R294
Gene Ontology
Molecular Function
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0047969 glyoxylate oxidase activity
Biological Process
GO:0001561 fatty acid alpha-oxidation
GO:0006545 glycine biosynthetic process
GO:0006979 response to oxidative stress
GO:0008652 amino acid biosynthetic process
GO:0046296 glycolate catabolic process
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle

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Cellular Component
External links
PDB RCSB:7r4o, PDBe:7r4o, PDBj:7r4o
PDBsum7r4o
PubMed
UniProtQ9UJM8|HAOX1_HUMAN 2-Hydroxyacid oxidase 1 (Gene Name=HAO1)

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