Structure of PDB 7r4j Chain A

Receptor sequence
>7r4jA (length=340) Species: 9606 (Homo sapiens) [Search protein sequence]
GGFRPSRVVVVAKTTRYEFEQQRYRYLLALKGSSYSGLLERHHIHTKNVE
HIIDSLRNEGIEVRLVKRREYDEETVRWADAVIAAGGDGTMLLAASKVLD
RLKPVIGVNTDPERSEGHLCLPVRYTHSFPEALQKFYRGEFRWLWRQRIR
LYLEGTGINPVPVDLHEASGPQLLPVRALNEVFIGESLSSRASYYEISVD
DGPWEKQKSSGLNLCTGTGSKAWSFNINRVATQAVEDVLNIAKRSLPLNR
ELVEKVTNEYNESLLYSPEEPKILFSIREPIAVFSSSRQRCFSSKVCVRS
RCWDACMVVDGGTSFEFNDGAIASMMINKEDELRTVLLEQ
3D structure
PDB7r4j Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation.
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.23: NAD(+) kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E123 D127 E50 D54
BS02 CA A G230 E418 G157 E316
Gene Ontology
Molecular Function
GO:0003951 NAD+ kinase activity
Biological Process
GO:0006741 NADP biosynthetic process
GO:0019674 NAD metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7r4j, PDBe:7r4j, PDBj:7r4j
PDBsum7r4j
PubMed35868311
UniProtQ4G0N4|NAKD2_HUMAN NAD kinase 2, mitochondrial (Gene Name=NADK2)

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