Structure of PDB 7r3l Chain A

Receptor sequence
>7r3lA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQA
KKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRGTYFAVNANYSAN
DTYSRPDANGRKHVYYVRVLTGIYTHGVPPSKDLYDTVTDNVHHPSLFVA
FYDYQAYPEYLITFRK
3D structure
PDB7r3l [1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I1Q A H1682 G1683 Y1714 Y1721 S1722 Y1727 H70 G71 Y90 Y97 S98 Y103
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7r3l, PDBe:7r3l, PDBj:7r3l
PDBsum7r3l
PubMed36598465
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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