Structure of PDB 7r3e Chain A

Receptor sequence
>7r3eA (length=545) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
QGHMLRLSAPGQLDDDLCLLGDVQVPVFLLRLGEASWALVEGGISRDAEL
VWADLCRWVADPSQVHYWLITHKHYDHCGLLPYLCPRLPNVQVLASERTC
QAWKSESAVRVVERLNRQLLRAEQRLPEACAWDALPVRAVADGEWLELGP
RHRLQVIEAHGHSDDHVVFYDVRRRRLFCGDALGEFDEAEGVWRPLVFDD
MEAYLESLERLQRLPTLLQLIPGHGGLLRGRLAADGAESAYTECLRLCRR
LLWRQSMGESLDELSEELHRAWGGQSVDFLPGELHLGSMRRMLEILSRQA
LPLDMRNDGGFLLWWDGLRSEMQPIHDSQGVFAVLEKEVRRLGFDYYAYG
VRHTIPFTRPKTEVHGTYPKAWLERYQMQNYGAVDPAILNGLRSSEMVVW
SDSLFDQSRMLWNEARDWGLCVGATLPIRAPNNLLSVLSVARDQQNISSF
EREEIRLRLRCMIELLTQKLTDLEHPMLMSNPVCLSHREREILQWTADGK
SSGEIAIILSISESTVNFHHKNIQKKFDAPNKTLAAAYAAALGLI
3D structure
PDB7r3e Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa.
ChainA
Resolution3.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.2.32: 2-aminobenzoylacetyl-CoA thioesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A D73 H74 D178 H221 D76 H77 D181 H224
BS02 FE A H69 H71 H159 D178 H72 H74 H162 D181
BS03 K5G A A375 V391 G393 Y395 W399 L400 D412 I415 W427 S466 A348 V364 G366 Y368 W372 L373 D385 I388 W400 S439
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0001216 DNA-binding transcription activator activity
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0016787 hydrolase activity
GO:0038023 signaling receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0009372 quorum sensing
GO:0010467 gene expression
GO:0044550 secondary metabolite biosynthetic process
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:0046889 positive regulation of lipid biosynthetic process
GO:0062162 positive regulation of pyocyanine biosynthetic process
GO:1900378 positive regulation of secondary metabolite biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0032993 protein-DNA complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r3e, PDBe:7r3e, PDBj:7r3e
PDBsum7r3e
PubMed36456567
UniProtP20581|PQSE_PSEAE 2-aminobenzoylacetyl-CoA thioesterase (Gene Name=pqsE);
P54292|RHLR_PSEAE HTH-type quorum-sensing regulator RhlR (Gene Name=rhlR)

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