Structure of PDB 7r38 Chain A

Receptor sequence

>7r38A (length=421) Species: 2261 (Pyrococcus furiosus)

MDCGKDYCVKDLSLAEEGWKKIDWVSRFMPVLQYIKREFEEKKPFKGVRI
AATLHLEMKTAFLLLTLKAGGAEVSAAASNPLSTQDDVVAALAKAGVKVY
AIRGESREQYYEFMHKALDIRPNIIIDDGADMISLVHKERQEMLDEIWGG
SEETTTGVIRLRAMEKAGILKFPVIAVNDSYMKYLFDNRYGTGQSTWDGI
MRATNLLIAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEAR
MDGFLVMDMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFD
VEIWKPDLEKLAVEINNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGH
PAEIMDMSFALQAKAAEYIKDNHERLEPKVYILPREIDEMVARIKLESMG
IKIEELTEEQKKYLESWEHGT

3D structure

• PDB: 7r38 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pyrococcus furiosus in complex with S-inosyl-L-homocysteine
• Chain: A
• Resolution: 2.05 Å

Enzymatic activity

• Enzyme Commision number: 3.13.2.1: adenosylhomocysteinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SIB	A	H55 E57 K59 S79 N80 D128 E153 T154 K183 D187 H298 F299 L341 L344 H350 M355 F359	H55 E57 K59 S79 N80 D128 E153 T154 K183 D187 H298 F299 L341 L344 H350 M355 F359
BS02	NAD	A	T154 T155 T156 N188 T192 V216 G217 G219 W220 C221 V239 E240 V241 K245 T273 N275 A296 G297 N343 H350	T154 T155 T156 N188 T192 V216 G217 G219 W220 C221 V239 E240 V241 K245 T273 N275 A296 G297 N343 H350

Gene Ontology

Molecular Function

• GO:0004013 adenosylhomocysteinase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006730 one-carbon metabolic process
• GO:0033353 S-adenosylmethionine cycle
• GO:0071269 L-homocysteine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7r38, PDBe:7r38, PDBj:7r38
• PDBsum: 7r38
• PubMed: 38548921
• UniProt: P50251|SAHH_PYRFU Adenosylhomocysteinase (Gene Name=ahcY)