Structure of PDB 7r2t Chain A

Receptor sequence
>7r2tA (length=416) Species: 9606 (Homo sapiens) [Search protein sequence]
YLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALD
GRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQGSA
YGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAF
AYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGT
DEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVA
LAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVP
HLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADR
LYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDT
KGDYQKALLYLCGGDD
3D structure
PDB7r2t SYNJ2BP PDZ domain in complex with a synthetic Vangl2 peptide.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L23 F25 N26 I27 V28 Q33 R46 H78 V82 F85 R86 L17 F19 N20 I21 V22 Q27 R40 H72 V76 F79 R80
BS02 CA A G133 E136 G127 E130
BS03 CA A G285 R288 K289 G290 E330 G279 R282 K283 G284 E324
BS04 CA A M361 G363 G365 D405 M355 G357 G359 D399
Gene Ontology
Molecular Function
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008092 cytoskeletal protein binding

View graph for
Molecular Function
External links
PDB RCSB:7r2t, PDBe:7r2t, PDBj:7r2t
PDBsum7r2t
PubMed38142947
UniProtP57105|SYJ2B_HUMAN Synaptojanin-2-binding protein (Gene Name=SYNJ2BP)

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