Structure of PDB 7r2m Chain A

Receptor sequence
>7r2mA (length=417) Species: 9606 (Homo sapiens) [Search protein sequence]
DYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAAL
DGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQGS
AYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIA
FAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLG
TDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMV
ALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSV
PHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFAD
RLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQD
TKGDYQKALLYLCGGDD
3D structure
PDB7r2m SYNJ2BP PDZ domain in complex with a synthetic Vangl2 peptide.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L23 F25 N26 I27 V28 Q33 K48 H78 V82 F85 R86 L18 F20 N21 I22 V23 Q28 K43 H73 V77 F80 R81
BS02 CA A G133 V134 G128 V129
BS03 CA A G285 R288 K289 G290 E330 G280 R283 K284 G285 E325
BS04 CA A M361 G363 G365 D405 M356 G358 G360 D400
BS05 CA A V331 K332 V326 K327
Gene Ontology
Molecular Function
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008092 cytoskeletal protein binding

View graph for
Molecular Function
External links
PDB RCSB:7r2m, PDBe:7r2m, PDBj:7r2m
PDBsum7r2m
PubMed38142947
UniProtP57105|SYJ2B_HUMAN Synaptojanin-2-binding protein (Gene Name=SYNJ2BP)

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