Structure of PDB 7r0q Chain A

Receptor sequence
>7r0qA (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
SLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHKE
3D structure
PDB7r0q Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
ChainA
Resolution1.95 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H0O A G10 C12 K16 A59 G60 Q61 R68 D69 M72 Y96 Q99 G10 C12 K16 A59 G60 Q61 R68 D69 M72 Y96 Q99
BS02 GDP A G13 G15 K16 S17 A18 F28 D30 N116 K117 D119 S145 A146 K147 G13 G15 K16 S17 A18 F28 D30 N116 K117 D119 S145 A146 K147
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7r0q, PDBe:7r0q, PDBj:7r0q
PDBsum7r0q
PubMed35404998
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

[Back to BioLiP]