Structure of PDB 7qy0 Chain A

Receptor sequence
>7qy0A (length=472) Species: 9606 (Homo sapiens) [Search protein sequence]
YQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKN
HPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNG
VCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDD
GKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYT
NSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQK
CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAN
DWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPK
DIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPM
GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANN
YGTLTKFTLVLYGTASGSLVPR
3D structure
PDB7qy0 Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.75: furin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I0T A M226 L227 E236 L240 W254 G255 G265 A267 W291 Y308 M117 L118 E127 L131 W145 G146 G156 A158 W182 Y199
BS02 CA A D174 D179 D181 D65 D70 D72
BS03 CA A D115 D162 V205 N208 V210 G212 D6 D53 V96 N99 V101 G103
BS04 CA A D258 D301 E331 D149 D192 E222
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7qy0, PDBe:7qy0, PDBj:7qy0
PDBsum7qy0
PubMed35377598
UniProtP09958|FURIN_HUMAN Furin (Gene Name=FURIN)

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