Structure of PDB 7qxy Chain A

Receptor sequence
>7qxyA (length=473) Species: 9606 (Homo sapiens) [Search protein sequence]
VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEK
NHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANN
GVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPED
DGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGY
TNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQ
KCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNA
NDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEP
KDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSP
MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEAN
NYGTLTKFTLVLYGTASGSLVPR
3D structure
PDB7qxy Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism.
ChainA
Resolution1.478 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.75: furin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D174 D179 D181 D66 D71 D73
BS02 CA A D115 D162 V205 N208 V210 G212 D7 D54 V97 N100 V102 G104
BS03 CA A D258 D301 E331 D150 D193 E223
BS04 I1G A M226 E236 L240 W254 G255 D264 G265 A267 W291 Y308 M118 E128 L132 W146 G147 D156 G157 A159 W183 Y200
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7qxy, PDBe:7qxy, PDBj:7qxy
PDBsum7qxy
PubMed35377598
UniProtP09958|FURIN_HUMAN Furin (Gene Name=FURIN)

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