Structure of PDB 7qwk Chain A

Receptor sequence
>7qwkA (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
FSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRR
IKGEVTLLSRLHHENIVRYYNAWIERHVHYLYIQMEYCEKSTLRDTIDQG
LYRDTVRLWRLFREILDGLAYIHEKGMIHRNLKPVNIFLDSDDHVKIGDF
GLGTALYVSPEVQGSTYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQ
LRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKS
3D structure
PDB7qwk The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G41 A L596 A617 M802 Y804 C805 S808 D812 F855 D866 L14 A35 M85 Y87 C88 S91 D95 F138 D149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7qwk, PDBe:7qwk, PDBj:7qwk
PDBsum7qwk
PubMed31868900
UniProtQ9P2K8|E2AK4_HUMAN eIF-2-alpha kinase GCN2 (Gene Name=EIF2AK4)

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