Structure of PDB 7qw7 Chain A

Receptor sequence

>7qw7A (length=553) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence]

TVSRQKATGAHFTPDKLAEVIAKRILDYFKGEKNRVIRVLDPACGDGELL
LAINKVAQSMNIQLELIGVDFDIDAINIANERLSRSGHKNFRLINKDFLE
MEELEPVDIIIANPPYVRTQILGAEKAQKLREKFNLKGRVDLYQAFLVAM
TQQLKSNGIIGVITSNRYLTTKGGESTRKFLVSNFNILEIMDLGDSKFFE
AAVLPAIFFGEKKNKEYQSNVPKFFKIYEQSDIEASSSVNSEFNSLIELL
EVNKSGLYSVEDKTYSISLGKIISPENYKEPWILATEDEYEWFMKVNQNA
YGFIEDFAHVKVGIKTTADSVFIRSDWGELPEEQIPEDKLLRPIISADQA
NKWSVSLVGNNKKVLYTHEIRDGQIKAINLEEFPRAKNYLESHKERLASR
KYVLKANRNWYEIWVPHDPSLWDKPKIIFPDTSPEPKFFYEDKGSVVDGN
CYWIIPKKENSNDILFLIMGICNSKFMSKYHDIAFQNKLYAGRRRYLTQY
VNKYPIPDPESIYSKEIISLVRELVNNKKETQDINEIENRIEKLILRAFD
IES

3D structure

PDB

7qw7 Structure of M.BseCI DNA methyltransferase from Geobacillus stearothermophilus.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	K14 G17 H19 N133 P134 Y136 R138 R159 R187 T191 K192 G193 A221 A222 K334 V335 Y475 Y513 R518 T521 Q522	K6 G9 H11 N113 P114 Y116 R118 R139 R167 T171 K172 G173 A201 A202 K311 V312 Y452 Y490 R495 T498 Q499
BS02	dna	A	Q140 A144 R151 G158 R159 K338 T340 D342 Y425 W437 T455 N473 R516	Q120 A124 R131 G138 R139 K315 T317 D319 Y402 W414 T432 N450 R493
BS03	SAH	A	G17 H19 F20 T21 A51 C52 D78 F79 D105 F106 N133 F166	G9 H11 F12 T13 A43 C44 D70 F71 D97 F98 N113 F146

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0008168	methyltransferase activity
GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity

	Biological Process
GO:0006304	DNA modification
GO:0009307	DNA restriction-modification system
GO:0032259	methylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7qw7, PDBe:7qw7, PDBj:7qw7
PDBsum	7qw7
PubMed
UniProt	P43423\|MTC1_GEOSE Type II methyltransferase M.BseCI (Gene Name=bseCIM)

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