Structure of PDB 7qw6 Chain A

Receptor sequence

>7qw6A (length=556) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence]

TVSRQKATGAHFTPDKLAEVIAKRILDYFKGEKNRVIRVLDPACGDGELL
LAINKVAQSMNIQLELIGVDFDIDAINIANERLSRSGHKNFRLINKDFLE
MEELEPVDIIIANPPYVRTQILGAEKAQKLREKFNLKGRVDLYQAFLVAM
TQQLKSNGIIGVITSNRYLTTKGGESTRKFLVSNFNILEIMDLGDSKFFE
AAVLPAIFFGEKKNKEYQKENSNVPKFFKIYEQSDIEASSSVNSEFNSLI
ELLEVNKSGLYSVEDKTYSISLGKIISPENYKEPWILATEDEYEWFMKVN
QNAYGFIEDFAHVKVGIKTTADSVFIRSDWGELPEEQIPEDKLLRPIISA
DQANKWSVSLVGNNKKVLYTHEIRDGQIKAINLEEFPRAKNYLESHKERL
ASRKYVLKANRNWYEIWVPHDPSLWDKPKIIFPDTSPEPKFFYEDKGSVV
DGNCYWIIPKKENSNDILFLIMGICNSKFMSKYHDIAFQNKLYAGRRRYL
TQYVNKYPIPDPESIYSKEIISLVRELVNNKKETQDINEIENRIEKLILR
AFDIES

3D structure

PDB

7qw6 Structure of M.BseCI DNA methyltransferase from Geobacillus stearothermophilus.

Chain

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	K14 G17 H19 N133 P134 Y136 R138 R159 R187 T191 K192 G193 F219 A221 A222 K334 V335 Y475 Y513 R518 T521 Q522	K6 G9 H11 N113 P114 Y116 R118 R139 R167 T171 K172 G173 F199 A201 A202 K314 V315 Y455 Y493 R498 T501 Q502
BS02	dna	A	T139 Q140 A144 R151 G158 R159 K338 T340 A341 D342 Y425 W437 T455 N473 Y513 A514 R516	T119 Q120 A124 R131 G138 R139 K318 T320 A321 D322 Y405 W417 T435 N453 Y493 A494 R496
BS03	SAH	A	T16 G17 H19 F20 T21 A51 C52 G53 L57 D78 F79 D105 F106 N133 F166	T8 G9 H11 F12 T13 A43 C44 G45 L49 D70 F71 D97 F98 N113 F146

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0008168	methyltransferase activity
GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity

	Biological Process
GO:0006304	DNA modification
GO:0009307	DNA restriction-modification system
GO:0032259	methylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7qw6, PDBe:7qw6, PDBj:7qw6
PDBsum	7qw6
PubMed
UniProt	P43423\|MTC1_GEOSE Type II methyltransferase M.BseCI (Gene Name=bseCIM)

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