Structure of PDB 7qvl Chain A

Receptor sequence
>7qvlA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMALSLTADQMVSALLDAEPPILYSEYSMMGLLTNLADRELVHMINWA
KRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLD
RNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYEE
KDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKG
MEHLYSMKSKNVVPSYDLLLEMLDAHRLHAP
3D structure
PDB7qvl Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GZI A L346 T347 L349 A350 D351 E353 F404 M421 G521 H524 L525 V533 V534 P535 L539 L35 T36 L38 A39 D40 E42 F93 M110 G200 H203 L204 V212 V213 P214 L218
External links
PDB RCSB:7qvl, PDBe:7qvl, PDBj:7qvl
PDBsum7qvl
PubMed36727211
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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