Structure of PDB 7qux Chain A

Receptor sequence
>7quxA (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
GSSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGK
YSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLAD
IVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHS
MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG
PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL
GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD
FLDKLLRYDHQSRLTAREAMEHPYFYTVVK
3D structure
PDB7qux Development of small cyclic peptides targeting the CK2 alpha / beta interface.
ChainA
Resolution1.48 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q36 Y39 Q40 L41 F54 V67 I69 D103 T108 Q37 Y40 Q41 L42 F55 V68 I70 D104 T109
BS02 ADP A S51 V53 V66 K68 V116 H160 M163 I174 D175 S52 V54 V67 K69 V117 H161 M164 I175 D176
BS03 MG A N161 D175 N162 D176
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7qux, PDBe:7qux, PDBj:7qux
PDBsum7qux
PubMed35343996
UniProtP68400|CSK21_HUMAN Casein kinase II subunit alpha (Gene Name=CSNK2A1)

[Back to BioLiP]