Structure of PDB 7qqh Chain A

Receptor sequence
>7qqhA (length=615) Species: 9606 (Homo sapiens) [Search protein sequence]
ELLDLKAGGFSIRNQKGEQVFRLAFRSGALDLDSCSRDGALLGCSLTADG
LPLHFFIQTVRPKDTVMCYRVRWEEGRAVEHAMFLGDAAAHWYGGAEMRT
QHWPIRLDGQQEPQPFVTSDVYSSDAAFGGILERYWLSSRAAAIKVNDSV
PFHLGWNSTERSLRLQARYHDTPYKPPAPELSYRVCVGSDVTSIHKYMVR
RYFNKPSRVPAPEAFRDPIWSTWALYGRAVDQDKVLRFAQQIRLHHFNSS
HLEIDDMYTPAYGDFDFDEVKFPNASDMFRRLRDAGFRVTLWVHPFVNYN
SSRFGEGVERELFVREPTGRLPALVRWWNGIGAVLDFTHPKARDWFQGHL
RRLRSRYSVASFKFDAGEVSYLPRDFSTYRPLPDPSVWSRRYTEMALPFF
SLAEVRVGYQSQNISCFFRLVNRDSVWGYDLGLRSLIPAVLTVSMLGYPF
ILPDMVGGNAVPQRTAGGDVPERELYIRWLEVAAFMPAMQFSIPPWRYDA
EVVAIAQKFAALRASLVAPLLLELAGEVTDTGDPIVRPLWWIAPGDETAH
RIDSQFLIGDTLLVAPVLEPGKQERDVYLPAGKWRSYKGELFDKTPVLLT
DYPVDLDEIAYFTWA
3D structure
PDB7qqh The primary familial brain calcification-associated protein MYORG is an alpha-galactosidase with restricted substrate specificity.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC A D213 W321 W426 R504 N520 D120 W223 W328 R406 N422
BS02 GLA A W321 D353 D354 W390 W426 K461 D463 R504 R517 N520 W223 D255 D256 W292 W328 K363 D365 R406 R419 N422
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7qqh, PDBe:7qqh, PDBj:7qqh
PDBsum7qqh
PubMed36129849
UniProtQ6NSJ0|MYORG_HUMAN Myogenesis-regulating glycosidase (Gene Name=MYORG)

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