Structure of PDB 7qpr Chain A

Receptor sequence

>7qprA (length=687) Species: 470 (Acinetobacter baumannii)

MPGEEVSQAKQQLKLIIDPYLSVSEVEKVLAACDFGDLAHTGITRKSGEP
YILHPIAVSCILANMRLDPETLMAALLHDVIEDTQYTKDDIIERFGQTVA
ELVDGVTKLSQSSDKEYNKAASFRKILQATLQDPRVIIIKLADRYHNMTT
LGALRPDKRARIAQETFDIFVPMARLVGMNEMADNLENLCYQNLDLDMFD
NVQNALLQTKPERCKYQSIWEQNLAELLHNYHIQGRIKKKNNNIELLRHF
VKNEMDLQELTHSHAFEIVLQSIADCDRLVAALKENFQVIQYQDHIRRPL
PGGNQSLMIKLKGEKTTLSLTIQTELMRKAARFGVVLGENAPQTCRSAIQ
ASMQNLNTLTTFNDLLDYLHQEKIWVYTPHGQLHELPQGATVVDFAYSAS
LFLGNHAVGAKVDGEIKPLSTPLVSGQVIEIITDVLATPNPDWLSFINTQ
KARRALQHVLKDQDIEEQRLVGAQALSRALKLFNRSINDLSDADWLDLLQ
WRHIDNKDALFEQIAVGDLLPQLVANHLFANDKHPNSDRLIQGTEGIDVK
YAHCCNPILGDPIQGHLTRRGLIVHRIRCHNLLHEQHLHPENIMPLQWKA
DDVDDVRFTAYLAIYMAMNDEQVSDLIYQCRKNNAGVEMVHSNEQRTFVN
IVVNNRKHIAKVIRDLRMHYGFPRIERLDAPAPQMEI

3D structure

• PDB: 7qpr Structure of full length SpoT
• Chain: A
• Resolution: 2.513 Å

Enzymatic activity

• Enzyme Commision number: 2.7.6.5: GTP diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	H54 H78 D79 D143	H54 H78 D79 D143
BS02	ZN	A	C565 H585 C589	C555 H575 C579
BS03	G4P	A	R45 K46 S113 N147 T150 K158	R45 K46 S113 N147 T150 K158

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008728 GTP diphosphokinase activity
• GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
• GO:0016301 kinase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0015969 guanosine tetraphosphate metabolic process
• GO:0015970 guanosine tetraphosphate biosynthetic process
• GO:0016310 phosphorylation
• GO:0042594 response to starvation

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:7qpr, PDBe:7qpr, PDBj:7qpr
• PDBsum: 7qpr
• UniProt: V5V8V7