Structure of PDB 7qk9 Chain A

Receptor sequence
>7qk9A (length=489) Species: 9606 (Homo sapiens) [Search protein sequence]
LPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKP
DVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALET
MDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHE
PIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSL
IKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAA
SRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASR
VFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELI
ESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPI
LKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYN
ALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLG
3D structure
PDB7qk9 Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3.
ChainA
Resolution1.782 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.1.36: retinal dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A I177 T178 P179 W180 K204 E207 G237 G241 F255 S258 V261 I158 T159 P160 W161 K185 E188 G218 G222 F236 S239 V242
Gene Ontology
Molecular Function
GO:0001758 retinal dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0042803 protein homodimerization activity
GO:0070324 thyroid hormone binding
GO:0070403 NAD+ binding
Biological Process
GO:0002072 optic cup morphogenesis involved in camera-type eye development
GO:0002138 retinoic acid biosynthetic process
GO:0006629 lipid metabolic process
GO:0006915 apoptotic process
GO:0007626 locomotory behavior
GO:0021768 nucleus accumbens development
GO:0031076 embryonic camera-type eye development
GO:0042472 inner ear morphogenesis
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
GO:0042574 retinal metabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043584 nose development
GO:0048048 embryonic eye morphogenesis
GO:0050885 neuromuscular process controlling balance
GO:0051289 protein homotetramerization
GO:0060013 righting reflex
GO:0060166 olfactory pit development
GO:0060324 face development
GO:0070384 Harderian gland development
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qk9, PDBe:7qk9, PDBj:7qk9
PDBsum7qk9
PubMed35418200
UniProtP47895|AL1A3_HUMAN Retinaldehyde dehydrogenase 3 (Gene Name=ALDH1A3)

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