Structure of PDB 7qie Chain A

Receptor sequence
>7qieA (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
DPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENL
PSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGRFLISYDR
TLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNED
SYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLN
KNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIDVYAIR
SAEGAPQKEVYFMGLIDILTQYDAKKVHPEQYAKRFLDFITNIF
3D structure
PDB7qie Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase gamma Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
ChainA
Resolution2.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.149: 1-phosphatidylinositol-5-phosphate 4-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DVF A D161 M162 N165 Y169 P183 F185 L273 I278 I373 D374 T377 D114 M115 N118 Y122 P136 F138 L226 I231 I266 D267 T270
Gene Ontology
Molecular Function
GO:0052742 phosphatidylinositol kinase activity
Biological Process
GO:0046488 phosphatidylinositol metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7qie, PDBe:7qie, PDBj:7qie
PDBsum7qie
PubMed35148092
UniProtQ8TBX8|PI42C_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Gene Name=PIP4K2C)

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