Structure of PDB 7qg5 Chain A

Receptor sequence
>7qg5A (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
FHSFSFYELKNVTNNFDERPINKMGEGGFGVVYKGYVNNTTVAVKKLEEL
KQQFDQEIKVMAKCQHENLVELLGFSCLVYVYMPNGSLLDRLSCLDGTPP
LSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGL
ARATVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVD
EHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLH
EKKNKRPDIKKVQQLLQEMT
3D structure
PDB7qg5 Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B7R A M192 G193 A211 K213 Y262 Y264 M265 P266 G268 L318 S328 M24 G25 A43 K45 Y80 Y82 M83 P84 G86 L136 S146
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7qg5, PDBe:7qg5, PDBj:7qg5
PDBsum7qg5
PubMed35439688
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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