Structure of PDB 7qg2 Chain A

Receptor sequence
>7qg2A (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVK
KLAELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLL
DRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE
AFTAKISDFGLARASVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVL
LEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVE
AMYSVASQCLHEKKNKRPDIKKVQQLLQEMT
3D structure
PDB7qg2 Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.
ChainA
Resolution3.031 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B6I A M192 G193 A211 Y262 Y264 M265 G268 L318 M29 G30 A48 Y91 Y93 M94 G97 L147
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7qg2, PDBe:7qg2, PDBj:7qg2
PDBsum7qg2
PubMed35439688
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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