Structure of PDB 7qg1 Chain A

Receptor sequence
>7qg1A (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
FHSFSFYELKNVTNNFDERPIGNKMGEGGFGVVYKGYVNNTTVAVKKLQQ
FDQEIKVMAKCQHENLVELLGFSCLVYVYMPNGSLLDRLSCLDGTPPLSW
HMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARA
VMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHRE
PQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKN
KRPDIKKVQQLLQEMT
3D structure
PDB7qg1 Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.
ChainA
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B8I A M192 A211 K213 Y262 Y264 M265 G268 D272 L277 L318 M25 A44 K46 Y77 Y79 M80 G83 D87 L92 L133
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7qg1, PDBe:7qg1, PDBj:7qg1
PDBsum7qg1
PubMed35439688
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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