Structure of PDB 7qfn Chain A

Receptor sequence
>7qfnA (length=360) Species: 9606 (Homo sapiens) [Search protein sequence]
ERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPG
LYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEH
KVEKVYVPALIFGQLLTSSNYDVTGGRNGYGAKLCNIFSTKFTVETACKE
YKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDI
VALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVA
LKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVG
KLIEVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSE
KFFKAASNCG
3D structure
PDB7qfn A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.
ChainA
Resolution2.621 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N107 I141 I157 F158 S164 S165 N166 G177 G180 A183 K184 N61 I95 I111 F112 S118 S119 N120 G126 G129 A132 K133
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7qfn, PDBe:7qfn, PDBj:7qfn
PDBsum7qfn
PubMed35660158
UniProtQ02880|TOP2B_HUMAN DNA topoisomerase 2-beta (Gene Name=TOP2B)

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