Structure of PDB 7qfb Chain A

Receptor sequence

>7qfbA (length=290) Species: 9606 (Homo sapiens)

GHMGSLNLDSIIGRLLEVQLTENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAY
KIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLP
IAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPD
KDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAK
RQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD

3D structure

• PDB: 7qfb Molecular architecture of the glycogen- committed PP1/PTG holoenzyme.
• Chain: A
• Resolution: 2.05 Å

Enzymatic activity

• Enzyme Commision number: 3.1.3.16: protein-serine/threonine phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R74 Y78 D166 E167 K168 D242 Y255 F257 R261 E287 L289 M290 C291 S292 F293 Q294 I295 L296 K297 P298 A299	R64 Y68 D156 E157 K158 D232 Y245 F247 R251 E277 L279 M280 C281 S282 F283 Q284 I285 L286 K287 P288 A289
BS02	MN	A	D92 N124 H173 H248	D82 N114 H163 H238
BS03	MN	A	D64 D92 H173 H248	D54 D82 H163 H238

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity

External links

• PDB: RCSB:7qfb, PDBe:7qfb, PDBj:7qfb
• PDBsum: 7qfb
• PubMed: 36261419
• UniProt: P62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)